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British Journal of Radiology (1992) 65, 273-278
© 1992 British Institute of Radiology
doi: 10.1259/0007-1285-65-771-273
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Three-dimensional imaging of dual isotope data-sets in a case of acute myocardial infarction

Hugo P. Dilhuydy, BIng Daniel McNamara, MD * Raymond J. Lemieux, MD * Yves Martel, BIng and Jacques A. de Guise, PhD

Institut de Génie Biomédical, Ecole Polytechnique de Montréal, Campus de I'Université de Montréal, Case Postale 6079, succursale "A", Montréal, Qué, H3C 3A7, Canada * Service de Médecine Nucléaire, Hôpital du Sacré-Cœur de Montréal, 5400 boul. Gouin ouest, Montréal, Qué, H4J 1C5, Canada

This excerpt was created in the absence of an abstract.

A patient with acute myocardial infarction was injected with indium 111 (111In)-antimyosin Fab. He then under-went planar imaging before receiving an additional dose of thallium 201 (2O1T1) so as to perform a dual isotope single photon emission computed tomography (SPECT) acquisition. Planar images showed vague myocardial uptake of antimyosin antibody. With tomographic slices, a more defined area of antimyosin uptake was seen but still with a low 111In signal-to-noise ratio. This area corresponded to a 2O1T1 defect. Two three-dimensional (3D) rendering methods showed a well matched 2O1T1 3D defect and 111In 3D hot spot and seemed to facilitate the localization of the infarct as well as the evaluation of its importance relative to the remaining viable tissue. This case study illustrates a situation where 3D imaging of dual isotope data-sets could be useful for direct visualization and localization of myocardial infarction.

A 61-year-old white male with a past history of occasional chest pain was admitted to the ICU for prolonged chest pain. He had multiple risk factors for coronary disease such as smoking (up to 40 cigarettes per day), essential hypertension, diabetes and a family history of coronary artery disease. Laboratory analysis showed elevated plasma enzyme levels of total creatine kinase (CK) (1289 U/l) and the electro-cardiogram showed an infarct in the anterior wall and a possible old inferior wall infarction (see Fig. 1). Five days after his admission coronary angiography revealed severe three-vessel disease.

Key Words: Myocardial infarction • Thallium 201 • Indium 111-antimyosin • Dual isotope • Three-dimensional imaging

Received for publication December 6, 1990. Revision received May 30, 1991. Accepted for publication September 4, 1991.






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