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Mitomycin C, 5-fluorouracil and radiation in advanced, locally recurrent rectal cancer

Department of Radiotherapy and Radiobiology, Allgemeines Krankenhaus der Stadt Wien, University of Vienna, Alser Str. 4, A-1090 Vienna, Austria

15 patients with inoperable presacral recurrent rectal cancer following surgery were treated with combined radiation and chemotherapy. Treatment consisted of split-course radiotherapy with 50 Gy in 25 fractions over 5 weeks and, after 4 weeks, an additional 20 Gy in 10 fractions over 2 weeks. At the start of treatment and following the split course, chemotherapy was administered. Mitomycin C was given on Day 1 (dose: 15 mg/m² i.v. bolus) and 5-fluorouracil from Day 1 to Day 5 (dose: 750 mg/m²/24 h, continuous i.v. infusion). Owing to considerable, predominantly haematological and gastrointestinal toxicity, only six out of 15 patients received treatment according to the protocol. The symptomatic relief of symptoms was good. Pain was controlled in seven of eight symptomatic patients. Seven of the patients showed response according to computed tomography, but in none of these cases was a complete remission seen. After a follow-up of at least 30 months, only three patients are alive. The 1-, 2- and 3-year survival rates are 9/15, 6/15 and 3/12, respectively. The median survival is 14 months (range 4–60+ months). In comparison with historical data from the same institution, combined radio-chemotherapy did not show any prolongation of survival or increased response rate, but increased toxicity excessively, when compared with radiation alone.

Key Words: Recurrent rectal cancer • Mitomycin C • 5-Fluorouracil • Radiotherapy

Received for publication January 10, 1991. Revision received April 18, 1991. Accepted for publication June 25, 1991.

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