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The labelling index in carcinoma of the uterine cervix: its correlation with tumour sterilization

J. L. Lagrange, MD A. Courdi, MD P. Chauvel, MD J. Gioanni, PhD ^* F. Ettore, MD A. Bongain, MD Th. Duforestel, MD and J. Y. Gillet, MD

Department of Radiotherapy, Centre A. Lacassagne, 36 Voie Romaine 06054 Nice, France ^* Biocancerology Laboratory, Centre A. Lacassagne, 36 Voie Romaine 06054 Nice, France Department of Pathology, Centre A. Lacassagne, 36 Voie Romaine 06054 Nice, France Department of Obstetrical Gynaecology and Reproductive Medicine, Hôpital Saint Roch, 5 Rue Pierre Devoluy, 06031 Nice, France

The pre-treatment labelling index (LI) was measured in 72 patients with carcinoma of the cervix. It was not correlated with patient age, stage of the disease or histological grade. 46 patients underwent hysterectomy after intracavitary irradiation with or without external radiotherapy. The mean LI in patients with tumour sterilization or microscopic residue was significantly higher than in patients with gross disease. These results suggest that tumours with low LI may be difficult to sterilize with conventional therapeutic measures, or that doomed cells may require several weeks to be eliminated in tumours with low LI.

Key Words: Carcinoma of the cervix • Labelling index • Cell proliferation • Tumour sterilization • Cell kinetics

Received for publication February 13, 1991. Revision received May 15, 1991. Accepted for publication June 13, 1991.