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British Journal of Radiology (1992) 65, 39-43
© 1992 British Institute of Radiology
doi: 10.1259/0007-1285-65-769-39
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Magnetization transfer contrast (MTC) imaging of skeletal muscle at 0.26 Tesla — changes in signal intensity following exercise

X. P. Zhu, MD S. Zhao, PhD and I. Isherwood, MD, FRCP, FRCR

Department of Diagnostic Radiology, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT

Magnetization transfer contrast (MTC) imaging of skeletal muscle before and after exercise has been studied in normal volunteers at 0.26 Tesla. A saturation pulse was applied over a range of offset frequencies immediately before a gradient recall echo sequence. Substantial signal loss was observed in all muscles. After exercise, selective saturation resulted in a significant increase of contrast between active and less active muscle, a phenomenon attributable to an increase in extracellular water content. MTC imaging provides a more sensitive method to detect changes in water distribution in human skeletal muscle.

Key Words: MRI • Magnetization transfer contrast • Muscle • Exercise

Received for publication March 5, 1991. Revision received July 2, 1991. Accepted for publication July 23, 1991.






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