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Tumour size as a prognostic factor in carcinoma of the cervix: assessment by transrectal ultrasound

B. J. Magee, MB, MRCP (UK), FRCR J. P. Logue, MB, MRCP (UK), FRCR R. Swindell, MSc, FSS ^* and D. McHugh, BSc, MSc

Departments of Radiotherapy and Oncology, Christie Hospital and Holt Radium Institute, Manchester M20 9BX, UK ^* Medical Statistics, Christie Hospital and Holt Radium Institute, Manchester M20 9BX, UK Medical Physics, Christie Hospital and Holt Radium Institute, Manchester M20 9BX, UK

Correspondence: Author for correspondence: J. P. Logue.

Transrectal ultrasound (TRUS) was used to measure tumour size in patients with carcinoma of the cervix and to assess its prognostic significance. Clinical staging was conducted and at the time of examination under anaesthesia, TRUS was used to assess maximum transverse diameter of the tumour. Eighty-one patients were studied. FIGO stages were 1B 34 patients, IIA seven patients, IIB 31 patients, IIIA two patients and IIIB seven patients. Mean tumour diameters by stage were IB 37 mm, IIA 37 mm, IIB 49 mm, IIIA 42 mm and IIIB 50 mm. There was a significant correlation between size and stage (p = 0.001). With a median follow-up of 18 months, 16 relapses have occurred. The actuarial relapse rates at median follow-up by stage were IB 10%, IIA 17%, IIB 22%, IIIA 0% and IIIB 35%. The actuarial relapse rates by size grouping at median follow-up were less than 30 mm 0%, greater than 30 and less than 40 mm 11%, greater than 40 and less than 50 mm 22%, and greater than 50 mm 38%. There was a significant difference between the mean recorded size of the tumours in the relapsed group and the relapse-free group (p = 0.02). Despite the small number of patients and short follow-up, tumour size as measured by TRUS appears to predict relapse.

Key Words: Carcinoma • Cervix • Transrectal • Ultrasound

Received for publication October 1, 1990. Revision received November 1, 1990.