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Ovarian ablation failures by radiation: a comparison of two dose schedules

Department of Clinical Oncology, Prince of Wales Hospital, Hong Kong

Sixty Chinese breast cancer patients underwent ovarian irradiation with one of two dose schedules: 12 Gy/4 fractions/4–6 days or 14 Gy/4 fractions/4–6 days. The ovarian ablation failure rates were 14% and 0% respectively in patients above 40 years of age. The overall ablation failure rate in younger patients was unacceptably high at 35%. The significance of the findings is discussed.

Key Words: Breast cancer • Menopause • Ovary • Radiotherapy

Received for publication October 1, 1990. Revision received January 1, 1991.

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