This Article Full Text (PDF) Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Miles, K. A. Search for Related Content PubMed PubMed Citation Articles by Miles, K. A.

Measurement of tissue perfusion by dynamic computed tomography

Departments of Radiology and Nuclear Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK

A method for quantifying tissue perfusion by dynamic computed tomography (CT) is described. By applying a nuclear medicine data processing technique to time-density data from a single-location dynamic CT sequence, tissue perfusion can be determined from the maximum gradient of the tissue time-density curve divided by the peak enhancement of the aorta. Using this method, splenic perfusion was measured at 1.2 ml min–¹ ml–¹, normal renal cortical perfusion at 2.5 ml min–¹ ml–¹ and normal renal medullary perfusion at 1.1 ml min–¹ ml–¹. Changes in cortical and medullary perfusion in renal failure and hypertension were demonstrated. The ability of dynamic CT to provide quantitative functional information is not well recognized and is potentially of value when studying structures, such as the renal cortex and medulla, that cannot be anatomically resolved by standard functional imaging techniques.

Key Words: Dynamic • Computed tomography • Perfusion • Measurement

Received for publication July 1, 1990. Revision received December 1, 1990.

This article has been cited by other articles:

				N. Lassau, S. Koscielny, L. Albiges, L. Chami, B. Benatsou, M. Chebil, A. Roche, and B. J. Escudier Metastatic Renal Cell Carcinoma Treated with Sunitinib: Early Evaluation of Treatment Response Using Dynamic Contrast-Enhanced Ultrasonography Clin. Cancer Res., February 15, 2010; 16(4): 1216 - 1225. [Abstract] [Full Text] [PDF]

				O. Maksimovic, C. Schraml, J. T. Hartmann, M. Bitzer, C. D. Claussen, J. Pintoffl, and M. Horger Evaluation of Response in Malignant Tumors Treated With the Multitargeted Tyrosine Kinase Inhibitor Sorafenib: A Multitechnique Imaging Assessment Am. J. Roentgenol., January 1, 2010; 194(1): 5 - 14. [Abstract] [Full Text] [PDF]

				A.A. Konstas, G.V. Goldmakher, T.-Y. Lee, and M.H. Lev Theoretic Basis and Technical Implementations of CT Perfusion in Acute Ischemic Stroke, Part 1: Theoretic Basis AJNR Am. J. Neuroradiol., April 1, 2009; 30(4): 662 - 668. [Abstract] [Full Text] [PDF]

				A. L. Summerlin, M. E. Lockhart, A. M. Strang, P. N. Kolettis, N. S. Fineberg, and J. K. Smith Determination of Split Renal Function by 3D Reconstruction of CT Angiograms: A Comparison with Gamma Camera Renography Am. J. Roentgenol., November 1, 2008; 191(5): 1552 - 1558. [Abstract] [Full Text] [PDF]

				J. van den Hoff, V. Goh, E. Klotz, and Q. S. Ng Assessment of Lung Cancer Perfusion by Using Patlak Analysis: What Do We Measure? Radiology, June 1, 2007; 243(3): 907 - 908. [Full Text] [PDF]

				P. Workman, E. O. Aboagye, Y.-L. Chung, J. R. Griffiths, R. Hart, M. O. Leach, R. J. Maxwell, P. M. J. McSheehy, P. M. Price, and J. Zweit Minimally invasive pharmacokinetic and pharmacodynamic technologies in hypothesis-testing clinical trials of innovative therapies. J Natl Cancer Inst, May 3, 2006; 98(9): 580 - 598. [Abstract] [Full Text] [PDF]

				P. E. Bize, A. Platon, C. D. Becker, and P.-A. Poletti Perfusion Measurement in Acute Pancreatitis Using Dynamic Perfusion MDCT Am. J. Roentgenol., January 1, 2006; 186(1): 114 - 118. [Abstract] [Full Text] [PDF]

				A. Sitek and R. G. Sheiman Small-Bowel Perfusion Measurement: Feasibility with Single-Compartment Kinetic Model Applied to Dynamic Contrast-enhanced CT Radiology, November 1, 2005; 237(2): 670 - 674. [Abstract] [Full Text] [PDF]

				Y. Tsushima, K. Endo, C. Weidekamm, and T. Bader Portal Perfusion Measurement on Dynamic CT in Patients with Liver Cirrhosis Am. J. Roentgenol., September 1, 2005; 185(3): 813 - 813. [Full Text] [PDF]

				A Nakashige, J Horiguchi, A Tamura, T Asahara, F Shimamoto, and K Ito Quantitative measurement of hepatic portal perfusion by multidetector row CT with compensation for respiratory misregistration Br. J. Radiol., September 1, 2004; 77(921): 728 - 734. [Abstract] [Full Text] [PDF]

				B M Seddon and P Workman The role of functional and molecular imaging in cancer drug discovery and development Br. J. Radiol., December 1, 2003; 76(suppl_2): S128 - S138. [Abstract] [Full Text] [PDF]

				B. F. Tomandl, E. Klotz, R. Handschu, B. Stemper, F. Reinhardt, W. J. Huk, K.E. Eberhardt, and S. Fateh-Moghadam Comprehensive Imaging of Ischemic Stroke with Multisection CT RadioGraphics, May 1, 2003; 23(3): 565 - 592. [Abstract] [Full Text] [PDF]

				K A Miles and M R Griffiths Perfusion CT: a worthwhile enhancement? Br. J. Radiol., April 1, 2003; 76(904): 220 - 231. [Full Text] [PDF]

				Y. Tsushima, J. Aoki, K. Endo, and J.-F. Paul Underestimation of Renal Cortical Perfusion Calculated from Dynamic CT Data * Dr Paul responds: Radiology, August 1, 2002; 224(2): 613 - 614. [Full Text]

				J.-F. Paul, P. Ugolini, M. Sapoval, E. Mousseaux, and J.-C. Gaux Unilateral Renal Artery Stenosis: Perfusion Patterns with Electron-Beam Dynamic CT—Preliminary Experience Radiology, October 1, 2001; 221(1): 261 - 265. [Abstract] [Full Text] [PDF]

				K. A. Miles, M. R. Griffiths, and M. A. Fuentes Standardized Perfusion Value: Universal CT Contrast Enhancement Scale that Correlates with FDG PET in Lung Nodules Radiology, August 1, 2001; 220(2): 548 - 553. [Abstract] [Full Text] [PDF]

				J H Gillard, N M Antoun, N G Burnet, and J D Pickard Reproducibility of quantitative CT perfusion imaging Br. J. Radiol., June 1, 2001; 74(882): 552 - 555. [Abstract] [Full Text] [PDF]

				A. F. DeVries, J. Griebel, C. Kremser, W. Judmaier, T. Gneiting, A. Kreczy, D. Ofner, K.-P. Pfeiffer, G. Brix, and P. Lukas Tumor Microcirculation Evaluated by Dynamic Magnetic Resonance Imaging Predicts Therapy Outcome for Primary Rectal Carcinoma Cancer Res., March 1, 2001; 61(6): 2513 - 2516. [Abstract] [Full Text]

				G. Brix, M. L. Bahner, U. Hoffmann, A. Horvath, and W. Schreiber Regional Blood Flow, Capillary Permeability, and Compartmental Volumes: Measurement with Dynamic CT—Initial Experience Radiology, January 1, 1999; 210(1): 269 - 276. [Abstract] [Full Text]

				J. D. Eastwood, M. H. Lev, T. Azhari, T.-Y. Lee, D. P. Barboriak, D. M. Delong, C. Fitzek, M. Herzau, M. Wintermark, R. Meuli, et al. CT Perfusion Scanning with Deconvolution Analysis: Pilot Study in Patients with Acute Middle Cerebral Artery Stroke Radiology, January 1, 2002; 222(1): 227 - 236. [Abstract] [Full Text] [PDF]