This Article Full Text (PDF) Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Haylor, J. L. Articles by Morcos, S. K. Search for Related Content PubMed PubMed Citation Articles by Haylor, J. L. Articles by Morcos, S. K.

The effect of sodium iothalamate on the vascular resistance of the isolated perfused rat kidney

J. L. Haylor, BPharm, PhD A. A. El Sayed, MB, BCh ^* A. M. EI Nahas, FRCP, PhD and S. K. Morcos, FRCS, FFRRCSI, FRCR

Department of Pharmacology and Therapeutics, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF ^* Department of Renal Medicine, Northern General Hospital, Herries Road, Sheffield Department of Radiodiagnosis, Northern General Hospital, Herries Road, Sheffield

The direct effects of sodium iothalamate on renal vascular resistance (RVR) were examined using the isolated perfused rat kidney experimental model. A concentration-dependent biphasic change in RVR was produced with the hyperosmolar solution of sodium iothalamate [(Conray 420), 420 mgl/ml, 2500 mOsmol/kg/H₂O]. The response characterized by an initial fall followed by a prolonged increase in RVR on discontinuation of the iothalamate infusion. No significant change in RVR was observed when iothalamate was infused as an iso-osmotic solution (60 mgl/ml, 280 mOsmol/kg/H₂O) at a rate of 0.525 ml/min. to produce a concentration of 4.2 mgl/ml in the renal perfusate. We conclude that sodium iothalamate can exert direct biphasic effects on RVR which are mediated by its hyperosmolality rather than its chemical content.

Key Words: Contrast media • Nephrotoxicity • Isolated perfused rat kidney • Renal vascular resistance • Iothalamate

Received for publication September 1, 1989.

This article has been cited by other articles:

				T. G. Gleeson and S. Bulugahapitiya Contrast-Induced Nephropathy Am. J. Roentgenol., December 1, 2004; 183(6): 1673 - 1689. [Full Text] [PDF]

				S K Morcos Effects of radiographic contrast media on the lung Br. J. Radiol., May 1, 2003; 76(905): 290 - 295. [Abstract] [Full Text] [PDF]