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British Journal of Radiology (1989) 62, 1084-1088
© 1989 British Institute of Radiology
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The British Journal of Radiology, Vol 62, Issue 744 1084-1088, Copyright © 1989 by British Institute of Radiology

ARTICLES

Sublethal damage repair and radiosensitivity of human squamous cell carcinoma cells grown with different culture techniques

JH Schwachofer, RP Crooijmans, J van Gasteren, J Hoogenhout, CR Jerusalem and HB Kal
Department of Radiotherapy, University Hospital, Nijmegen, The Netherlands.

In this study, cells of a human squamous cell carcinoma line, HN-1, were grown in monolayers and as multicellular tumour spheroids (MTS). Repair of radiation-induced damage was studied by irradiation with single and split doses of X rays (4-8 Gy). It was shown that the amount of sublethal damage that was repaired in this dose range was equal in cells growing in monolayers and as MTS. The radiosensitivity of spheroids, as expressed by spheroid "cure" dose, increased with increasing MTS diameter. It is postulated that, in MTS with no signs of hypoxia, radioresistance diminishes when MTS increase in diameter.




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