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The evaluation of radioiodine therapy for thyroid patients using a fixed-dose regime

United Medical and Dental Schools of Guy's and St Thomas's Hospital, Department of Nuclear Medicine and Endocrinology, Guy's Hospital, London SE1

Ninety-six patients with toxic diffuse goitre (Graves' disease) in whom rapid control of disease was necessary were treated with an "ablative" dose of 550 MBq of radioiodine (¹³¹I) with the intention of inducing hypothyroidism. Outcome was established in 93 cases (mean follow-up 37 months), 45 patients (48%) becoming hypothyroid, 30 (32%) remaining euthyroid and 18 (19%) with persistent thyrotoxicosis requiring further ¹³¹I therapy. It is thus apparent that a fixed dose of 550 MBq ¹³¹I cannot be considered ablative, with less than 50% of patients developing hypothyroidism.

Received for publication March 1, 1986.

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