This Article Full Text (PDF) Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Dawson, P. Articles by Howell, M. Search for Related Content PubMed PubMed Citation Articles by Dawson, P. Articles by Howell, M.

The non-ionic dimers: a new class of contrast agents

Department of Diagnostic Radiology, Hammersmith Hospital, Du Cane Road, London W12 0HS ^* Department of Chemical Pathology, The Middlesex Hospital, Mortimer Street, London W1

Non-ionic dimers are a new class of iodinated radiological contrast agents. Some physico-chemical and pharmacological properties of three representative compounds are presented. Non-ionic dimers are iso-osmolar with plasma at all iodine concentrations unless diluted with saline and in terms of chemotoxicity they appear to be closely comparable with the established non-ionic monomeric agents. It is shown that the data lend support to the theory that it is the degree of steric hindrance of the hydrophobic iodine atoms by side-chains which determines this chemotoxicity. Areas in which agents of this type may find applications are indicated.

Received for publication October 1, 1985. Revision received May 1, 1986.

This article has been cited by other articles:

				S. Langner, S. Stumpe, M. Kirsch, M. Petrik, and N. Hosten No Increased Risk for Contrast-Induced Nephropathy after Multiple CT Perfusion Studies of the Brain with a Nonionic, Dimeric, Iso-Osmolal Contrast Medium AJNR Am. J. Neuroradiol., September 1, 2008; 29(8): 1525 - 1529. [Abstract] [Full Text] [PDF]

				P. A. McCullough, M. E. Bertrand, J. A. Brinker, and F. Stacul A Meta-Analysis of the Renal Safety of Isosmolar Iodixanol Compared With Low-Osmolar Contrast Media J. Am. Coll. Cardiol., August 15, 2006; 48(4): 692 - 699. [Abstract] [Full Text] [PDF]

				E. M. Baile, L. Wang, L. Verburgt, and P. D. Pare Bronchial vasodilatory response to ionic and nonionic contrast media J Appl Physiol, March 1, 1997; 82(3): 841 - 845. [Abstract] [Full Text] [PDF]