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British Journal of Radiology (1986) 59, 911-917
© 1986 British Institute of Radiology
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The British Journal of Radiology, Vol 59, Issue 705 911-917, Copyright © 1986 by British Institute of Radiology

ARTICLES

A comparison of the tumour concentrations obtainable with misonidazole and Ro 03-8799

S Dische, MI Saunders, MH Bennett, EP Dunphy, C Des Rochers, MR Stratford, AI Minchinton and P Wardman

Both Ro 03-8799 and misonidazole were administered to six patients before tumour sampling. Using similar doses, tumour concentrations of Ro 03-8799 were approximately double those of misonidazole. Examination of the data with regard to the relative sensitising efficiencies of these two compounds gives us, as a conservative estimate, a factor of 1.6 in favour of Ro 03-8799. From these observations it is predicted that, when given with radiotherapy in a 25-fraction course Ro 03-8799, is likely to be at least five times more effective as a hypoxic cell sensitiser than misonidazole.




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