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British Journal of Radiology (1986) 59, 389-395
© 1986 British Institute of Radiology
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The British Journal of Radiology, Vol 59, Issue 700 389-395, Copyright © 1986 by British Institute of Radiology

ARTICLES

The radiosensitivity of microcolony- and macrocolony-forming cells in mouse tail epidermis

FD Chen and JH Hendry

A new microcolony technique is described for measuring the survival of colony-forming cells in mouse tail epidermis. The survival curve is characterised by D0 = 2.70 +/- 0.12 Gy. The number of microcolonies per cm2 is similar to the number of macrocolonies after high doses, which shows for the first time that all microcolonies (greater than or equal to 32 cells) in epidermis develop into macrocolonies. At low doses the number of macrocolonies underestimates the number of colony-forming cells because of coalescence of microcolonies to form macrocolonies. This results in a lower apparent sensitivity of macrocolony-forming cells by a factor of about 1.5. About 3% of basal cells in tail epidermis appear to be capable of colony formation.


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G J M J van den Aardweg, G M Morris, A Bywaters, E J Bakker, and W J Mooi
Changes in epidermal radiosensitivity with time associated with increased colony numbers
Br. J. Radiol., May 1, 2001; 74(881): 434 - 444.
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