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British Journal of Radiology (1986) 59, 373-377
© 1986 British Institute of Radiology
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The British Journal of Radiology, Vol 59, Issue 700 373-377, Copyright © 1986 by British Institute of Radiology

ARTICLES

Report of a randomised pilot study of the treatment of patients with supratentorial gliomas using neutron irradiation

W Duncan, J McLelland, WJ Jack, SJ Arnott, A Gordon, GR Kerr and JR Williams

A randomised pilot study is reported of d(15)+Be neutrons compared with 4 MV photons in the treatment of patients with astrocytoma. Sixteen patients were treated by photons and 18 by neutrons. Both treatments were well tolerated by patients. The median survival after photons was 11 months and after neutrons, 7 months. It was demonstrated that four of nine patients treated by neutrons had evidence at autopsy of radiation-induced brain damage. All had residual cancer. No patient treated by photons had signs of radiation-related morbidity. The trial was, therefore, discontinued prematurely.




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