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British Journal of Radiology (1985) 58, 1023-1026
© 1985 British Institute of Radiology
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The British Journal of Radiology, Vol 58, Issue 694 1023-1026, Copyright © 1985 by British Institute of Radiology

ARTICLES

Irradiation depresses prostacyclin generation upon stimulation with the platelet-derived growth factor

H Sinzinger and W Firbas

Experimental and clinical findings demonstrated rather severe arterial lesions occurring in irradiated arteries. It is suggested that a local haemostatic imbalance might be one causative factor. Liberation of PDGF causes smooth-muscle cell proliferation and PGI2 formation by the arterial wall cells, inhibiting in turn further release of PDGF from the alpha granules of the platelets. A decreased ability of irradiated vascular segments to generate PGI2 upon PDGF stimulation described here might cause haemostatic imbalance and subsequent radiation-induced lesions.


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[Abstract] [Full Text]


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