BJR
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
British Journal of Radiology (1985) 58, 443-451
© 1985 British Institute of Radiology
doi:
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Camplejohn, R. S.
Right arrow Articles by Penhaligon, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Camplejohn, R. S.
Right arrow Articles by Penhaligon, M.

The British Journal of Radiology, Vol 58, Issue 689 443-451, Copyright © 1985 by British Institute of Radiology

ARTICLES

The tumour bed effect: a cell kinetic and histological investigation of tumours growing in irradiated mouse skin

RS Camplejohn and M Penhaligon

Most tumours grow more slowly when implanted into pre-irradiated sites--the tumour bed effect (TBE). The TBE is usually assayed by measuring the delay for tumours growing in irradiated sites compared with that for tumours growing in mock-irradiated sites to reach a certain arbitrary, externally-measured volume. The resulting X-ray dose-response curves for the TBE are generally S-shaped, with little effect up to doses of 5 Gy, a dose-dependent effect between 5 and 20 Gy and a plateau at higher doses. In this study such a dose-dependent TBE was demonstrated for two contrasting transplantable tumours (a rapidly growing mammary adeno-carcinoma and the RIF-1 fibrosarcoma) growing in the flank skin of C3H/He mice. Cell kinetic and histological methods were used to investigate the mechanism of the reduced tumour growth rate in irradiated sites. By combining information from tumour growth curves and metaphase-arrest lines, tumour cell birth and cell loss rates were estimated. In addition the necrotic and viable fractions of tissue were measured by means of Chalkley point counting. In both tumours, marked increases in cell loss rate and degree of necrosis were found to be dependent on the dose of X rays previously given to the stroma. Surprisingly, cell birth rate and mitotic index were significantly increased in mammary tumours growing in irradiated sites. The estimation of viable, as opposed to external, volume of tumours growing in sites which had received between 0 and 60 Gy X rays suggested that the conventional TBE assay method may underestimate the extent of the TBE and may distort the shape of the TBE dose response curve.


This article has been cited by other articles:


Home page
 Cancer Res.Home page
E. K. Rofstad, B. Mathiesen, K. Henriksen, K. Kindem, and K. Galappathi
The Tumor Bed Effect: Increased Metastatic Dissemination from Hypoxia-Induced Up-regulation of Metastasis-Promoting Gene Products
Cancer Res., March 15, 2005; 65(6): 2387 - 2396.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
BJR DMFR IMAGING  ALL BIR JOURNALS 
Copyright © 1985 by the British Institute of Radiology.