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BIR Bulletin

The superiority of non-ionic contrast media, especially metrizamide, over conventional media (Cardioconray and Urografin 370) has been shown with regard to the extent and duration of hypotension following aortic injection. This is likely to be of especial significance in those patients with generalized arteriosclerosis and limited cardiac reserve. Metrizamide (370 mg iodine/ml) causes a less marked and shorter fall in blood pressure than lopamidol (370 mg iodine/ml) and has less effect on the heart rate. The non-ionic contrast agents, metrizamide and lopamidol and also Hexabrix, cause much less pain and sensation of heat in the legs than Cardioconray and Urografin 370. Metrizamide has the disadvantage of needing to be dissolved from its powder form and is very expensive.