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British Journal of Radiology (1981) 54, 606-614
© 1981 British Institute of Radiology
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The British Journal of Radiology, Vol 54, Issue 643 606-614, Copyright © 1981 by British Institute of Radiology

ARTICLES

Negative pion depth-dose profile examined by means of HeLa cell-survival curves

DH Reading, MA Hynes, WS Spinks and AH Nias

HeLa cells were irradiated at liquid nitrogen temperature with negative pions from Nimrod at the Rutherford Laboratory and then assayed for survival of colony-forming ability. Complete dose-response curves were obtained from repeated determinations at 14 different positions along the depth-dose profile and survival curves were fitted to the data by computer programme. A depth-damage profile was thus established in terms of the final slopes of these survival curves. This confirmed the expected RBE value of 1.84 at the ionization peak. Although a value of unity was found in the main plateau region, the "entrance" positions showed significantly higher values.




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