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British Journal of Radiology (1981) 54, 245-249
© 1981 British Institute of Radiology
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The British Journal of Radiology, Vol 54, Issue 639 245-249, Copyright © 1981 by British Institute of Radiology

ARTICLES

Effect of hyperthermia on the hypoxic fraction in an experimental mammary carcinoma in vivo

J Overgaard

The influence of hyperthermia on the fraction of clonogenic hypoxic cells in a CaH mammary carcinoma was investigated using the TCD50 values for radiation treatment under normal or clamped conditions. A one-hour heat treatment at 41.5 and 42.5 degree C given four hours after radiation reduced the hypoxic fraction to 2.3 X 10(-1), 7.4 X 10(-3) and 6.5 X 10(-3) respectively, when compared with the content of hypoxic cells in non-heated tumours. The results indicate that moderate hyperthermia is able to destroy selectively a large proportion of the fraction of radioresistant hypoxic cells in a solid tumour. This effect is probably due to the increased heat sensitivity of cells in a chronically hypoxic and nutritionally deprived acidic environment.




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