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Care with radiosensitizers

Paterson Laboratories and Department of Radiotherapy, Christie Hospital and Holt Radium Institute, Manchester M20 9BX

This excerpt was created in the absence of an abstract.

Adams and Dische (1979) comment that the conclusion in our cautionary note (Hendry and Sutton, 1978) drawn from observations in mice, concerning possible radiosensitization of normal human tissues by misonidazole, is doubtful because of (1) relative tolerable drug doses, (2) single versus fractionated treatments, and (3) existing clinical experience.

1. It is unlikely that peak blood plasma levels of misonidazole higher than about 100 µg/ml will be achieved consistently in fractionated human treatments owing to toxicity (Dische et al., 1977).

Received for publication May 1, 1979.