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A radioprotective effect of vitamin C observed in Chinese hamster ovary cells

Department of Physics, College of Technology, Kevin Street, Dublin 8 and The Meath Hospital, Dublin 8

M. Moriarty, F.R.C.R., F.R.C.P.I., R.C.S.I. and S. Mulgrew, I.M.L.T.

Saint Luke's Hospital, Dublin 6

Vitamin C at high concentrations was found to inhibit the growth of CHO clone A cells in culture. It had a radioprotective effect, giving a maximum increase in cell survival of a factor of seven under the experimental conditions used. The protective effect was mainly but not exclusively attributable to an increase in the D₀, the maximum increase observed being the order of 1.4.

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