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British Journal of Radiology (1976) 49, 267-269
© 1976 British Institute of Radiology
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The British Journal of Radiology, Vol 49, Issue 579 267-269, Copyright © 1976 by British Institute of Radiology

ARTICLES

Technetium-99m labelled imidodiphosphate: an improved bone-scanning radiopharmaceutical

KR Brody, P Hosain, RP Spencer, F Hosain and HN Wagner

Technetium-99m labelled imidodiphosphate was prepared in the presence of stannous ions. It was evaluated as a bone-scanning agent in animals and patients. Comparative tissue distribution studies in mice showed a relatively higher uptake of radioactivity in bone when 99Tcm -labelled pyrophosphate and diphosphonate. Accumulation of radioactivity in soft tissues, especially kidneys, was less with this radiopharmaceutical. Results in patients were most satisfactory in delineating skeletal bone and identifying bone lesions with relatively small tracer doses of the radiopharmaceutical.


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