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British Journal of Radiology (1975) 48, 908-912
© 1975 British Institute of Radiology
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The British Journal of Radiology, Vol 48, Issue 575 908-912, Copyright © 1975 by British Institute of Radiology

ARTICLES

Damage and recovery assessment of the mouse jejunum to abdominal X-ray and adriamycin treatment

DR Burholt, RF Hagemann, JW Cooper, LL Schenken and S Lesher

The influence of adriamycin on the post-irradiation proliferative response of the mouse jejunum was examined. Doses of either 5 or 10 mg/kg of adriamycin administered immediately after abdominal irradiation reduced the LD50/7 days by 300-400 R. Neither dosage of the drug reduced the number of surviving crypts, as measured by the crypt isolation and microcolony techniques, for a given radiation exposure. However, both drug dosages reduced the amount of post-irradiation compensatory hyperplasia, as measured by 3H-thymidine incorporation.




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