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Meglumine diatrizoatex v. iothalamate: comparison of seizure-inducing potential

Departments of Radiology, University of California, San Diego, and The Clinical Center, National Institute of Health, Bethesda, Maryland

Methylglucamine iothalamate and methylglucamine diatrizoate were infused selectively into the lumbar artery supplying the lower spinal cord of ten dogs. Methylglucamine iothalamate caused no spontaneous seizures and stimulated seizures were observed only once. Methylglucamine diatrizoate precipitated seizures in two dogs and induced a state of spinal cord hyper-irritability in six. Methylglucamine iothalamate appears less epileptogenic than methylglucamine diatrizoate when perfused directly into spinal vessels.

^* Address for reprints: Building 10, Room 6S211 National Institute of Health, Bethesda, Maryland 20014.

Received for publication July 1, 1973.