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The late results of radium treatment for benign uterine haemorrhage

Marie Curie Unit, Mount Vernon Hospital, Northwood, Middlesex, and Department of Radiotherapy, The London Clinic, London, W.1.

A total of 1,817 patients treated at the Marie Curie Hospital with radium for functional uterine haemorrhage has been followed for at least ten years or until earlier death. A considerable increase in the incidence of uterine carcinoma was found in these patients and the possible causes are discussed. No significant increase in incidence of extra-uterine malignant disease or of leukaemia was demonstrated.

Permanent amenorrhoea was not produced in all patients and of more than 30 attempted pregnancies, six full-term births resulted. No genetic changes attributable to the irradiation have been noted in these or in one second generation offspring.

The conclusion is reached that if irradiation is used to produce an artificial menopause, external pelvic radiotherapy is to be preferred to intra-uterine radium.

Received for publication November 1, 1968.