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Radiation Dosimetry of the ¹³¹I-Hippuran Renogram

Departments of Radiotherapy, Physics and Biophysics, Royal Marsden Hospital and Institute of Cancer Research, Sutton, Surrey

Thirty patients have been studied by whole-body counting and thyroid uptake measurements following routine ¹³¹I-Hippuran renography, and the radiation dose to the kidneys, thyroid, bladder wall and gonads calculated. Most of the activity retained in the body was contained in the thyroid gland and derived from free-iodide in the injected material. The thyroid dose was of the order of 1 rem; this could be reduced by a factor of 7–10 by blocking the thyroid or by the use of iodide-free Hippuran. The gonad dose was less than 2 mrem, about 1 per cent of that from an intravenous pyelogram. It is concluded that renography constituted a negligible radiation hazard to the patient.

Received for publication September 1, 1966.