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The Effects of Cyclotron Neutrons on the Intact Mouse Thymus under Normal and Hypoxic Conditions

St. Mary's Hospital, London, W.2

D. K. Bewley, M.A., Ph.D. and C. J. Parnell, B.Sc.

M.R.C. Cyclotron Unit, Hammersmith Hospital, London, W.12

This excerpt was created in the absence of an abstract.

Mice have been irradiated with fast neutrons (mean energy 6 MeV) under normal and hypoxic conditions. Hypoxia was induced by brief periods of nitrogen breathing. Observations of the thymus weight two days later gave an oxygen enhancement ratio of 1·7 ± 0·2. Earlier irradiations with 8 MeV electrons gave an OER of 2·7 ± 0·3. This gives a gain factor of l·6 ± 0·2. The RBE relative to 8 MeV electrons is 2·35 in air and 3·82 in nitrogen.