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The Uptake of Phosphorus 32 by the Knee Joint and Tibia of Six-week-old Mice and the Effect of X Rays Upon it. Variation of Uptake with time after a Dose of 2000r of 200 kV X Rays

Physics Department, Westminster Hospital, London, S.W.1

This excerpt was created in the absence of an abstract.

Experiments are described which examine the effect of a single X-ray dose of 2000 r to the knee joint and tibia of six-week-old mice upon the uptake of ³²P in these bones at varying intervals after irradiation up to 22 weeks. It is shown that in the knee joint, after a latent period of about one week the uptake of ³²P falls progressively to reach a minimal value of about 55 per cent after about four weeks. The relationship of these results to those obtained by others for the depression of alkaline phosphatase activity is discussed. It is suggested that the time sequence of the irradiation effects involved may be suppression of osteoblastic activity leading to immediate and increasing depression of alkaline phosphatase activity as a result of which, after the latent period, new calcification is depressed in increasing amount until the maximum is reached. This depression is maintained until about eight to ten weeks after irradiation following which a slow recovery seems to occur, but this is still incomplete at the end of 22 weeks.

In the tibia similar effects of a similar magnitude were observed but they develop more slowly. This difference may be related to differences between the growth activity of the knee joint and tibia.

Accepted for publication February 1, 1955.