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Irregularities of Iodine Assimilation by the Follicles of the Rat Thyroid

Radiotherapy Department, Royal Victoria Infirmary, Newcastle upon Tyne

This excerpt was created in the absence of an abstract.

When radioactive iodine is taken up by the thyroid, there is a heterogenous distribution of radiation dose which depends upon the concentration of iodine in the follicles and their distribution. The worst practical case will occur if the follicles are arranged in clusters according to their size, when a dose ratio in the gland equal to the maximum ratio of the follicle iodine concentrations will result. In the normal rat thyroid this latter factor is approximately 5:1.