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Angiocardiographic Experiments on the Pathogenesis of Adrenalin Pulmonary dema in Rabbits

Radiologist to Manor House Hospital, London, N.W. 11

This excerpt was created in the absence of an abstract.

Angiocardiography was used in a study of the pathogenesis of adrenalin pulmonary œdema in rabbits and the adrenalin action on neurotropic substances. Adrenalin, followed by an opaque dye, was injected into the ear vein of rabbits. Radiographs taken immediately after the injections reveal the jugular veins filled to capacity with the opaque material. The dilated veins can be followed to the entrance into the right auricle and 40 seconds after the injection no opaque dye is visible in the left heart and aorta. Owing to increased pressure in the pulmonary circulation and the right heart the injected dyes take the route of least resistance and spread backwards into the peripheral tributaries of the jugular veins in the head.

The angiocardiographic experiments provide a satisfactory explanation for the hitherto puzzling adrenalin action on neurotropic substances. The radiographs reveal the gross circulatory disturbances produced by massive doses of adrenalin which seem to be similar to those occurring in acute pulmonary œdema of circulatory origin in human pathology. The possible significance of the recorded experiments with regard to cardiac asthma and pulmonary œdema is discussed. The theory is advanced that adrenalin or similar pressor substances may play an important part in the development of pulmonary œdema in cases in which function of the left ventricle is greatly impaired.