This Article Full Text (PDF) Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Paterson, E. Search for Related Content PubMed Articles by Paterson, E.

The Time-Intensity Factor in X-ray Irradiation

Southport Research Laboratories, The Christie Hospital and Holt Radium Institute, Manchester

This excerpt was created in the absence of an abstract.

1. Experiments on fibroblasts have demonstrated the influence of the overall time on radiation effect when the total dose and the dosage-rate per session were kept constant.

2. An increase of the overall time of radiation to 21 days increased the lethal effect when the dose was split into eleven sessions.

3. This increased effect was seen as a decreased proportion of survivors and a decreased survival time if the latter was calculated for long-term experiments from any pointsubsequent to the beginning of radiation.

4. A qualitative difference was also shown by a lessened variation from the median point of death and a failure of cultures to show the recovery phenomenon after long-term radiation.

5. The degree of splitting of long-term radiation was of importance in influencing the effects.

6. Some of the implications of these findings are discussed.