Figure 4. Effect of pharmacological interventions on the development of experimental radiation nephropathy after total body irradiation (TBI) plus bone marrow transplantation (BMT). Actual incidence curves are shown for animals that received 17 Gy TBI plus BMT and were treated with: angiotensin converting enzyme (ACE) inhibitors (low dose captopril, high dose captopril, or enalapril); an angiotensin II (AII) Type 1 receptor antagonist (L-158,809); or various other antihypertensives that act by mechanisms not directly related to AII activity (verapamil, hydralazine, hydrochlorothiazide and L-methyl-DOPA). Adapted with permission from Moulder et al [54].