Figure 2. Flow chart demonstrating the 36 possible combinations of confidence levels, diagnostic changes and ultimate diagnostic accuracy. Route Label: the italiczed labels (such as A1 and A3) are the same route labels as those in Figure 1. *Route score: this score was derived from a weighted average of the best estimate, pessimistic, and optimistic score (see Materials and methods section). For clarity, the underlying component scores have been presented, denoted as x (y, z) = best estimate (pessimistic, optimistic) scores. **Last row of flow chart = number of patients in each route in the case study.