Figure 6. Illustration of the usefulness of the massive training artificial neural network (MTANN) in reducing the number of false positives (FPs) in computerised detection of nodules in low dose CT (LDCT) images. Single MTANN or multi-MTANN was applied to a rule-based computer-aided diagnosis (CAD) scheme for 63 LDCT scans with 71 nodules including 66 primary cancers and 5 benign nodules.