Figure 5. The initial clinical assessment of the extended cranial-caudal mammogram (a) did not reveal any suspicious regions of interest. The medial-lateral oblique mammogram (b) was determined to have a slightly denser region (circled) but did not reveal any pathology with needle biopsy. After registration with the contrast-entranced MRI projections, the centroid of the region visible in the MRI was projected back onto the mammograms (indicated by +). Biopsy of this region tested positive for malignancy.