Figure 13. Curve fit of dynamic contrast enhanced data from (a) a low-grade and (b) a high-grade glioma showing curve fit performed with an extended pharmacokinetic model. Illustrated values show separate calculated estimates of flow (F) and permeability surface area product (PS) as well as the proportional blood volume (v_b) and the volume of the extravascular extracellular space (v_e). The original data (represented as circles) shows some significant spread around the curve fit due to inherent signal to noise characteristics despite the fact that this data was taken from large regions of interest rather than single voxels.