Figure 16. Changes in k_fp occurring as a result of administration of a vascular endothelial growth factor (VEGF) antagonist in groups of patients with advanced epithelial cancers. Note the immediate drop in k_fp as a result of the drug administration and the gradual recovery over the following months. Also note the dose effect with minimal effects seen at the lowest dose (0.3 mg kg^–1) and more marked effects at the higher dose regimens.