Figure 10. Example curve fits from data in (a) a grade 3 and (b) a grade 4 glioma. The fitting has been performed using the adiabatic model described by St Lawrence and Lee [40] and therefore gives individual estimates of flow (F), permeability–surface area product (PS), fractional vascular volume (v(b)) and fractional extravascular extracellular space volume (v(e)). (Cartesy of Dr D Buckley, University of Manchester.)