Figure 2. The effects of 10 mg kg^–1 CA-4-P on mean arterial blood pressure (MABP) and blood flow rate to the P22 tumour and selected normal tissues in the BDIX rat. MABP was measured via an intra-arterial cannula. Comparison of MABP and skeletal muscle blood flow results suggest that the initial hypertensive effect is due to vasoconstriction in muscle. Spleen is the most responsive normal tissue but the greatest effect is found in tumour. Blood flow rate was measured using the tissue uptake of radiolabelled iodo-antipyrine, where tracer concentration versus time curves for arterial blood and tissue are deconvolved to extract tissue blood flow rates for tumour and normal tissues. Values are the mean±1 standard error (SE). The shaded bars show the limits of the SE for the control animals. A significant difference from control at the 5% level is represented by *. Figure adapted from reference [80].