Figure 3. Time course of renal function after injection of diatrizoate in rats pre-treated with indomethacin and L-nitroarginine methyl ester (L-NAME). Significant increase (^*p<0.01) in serum creatinine (Cr) occurred 24 h after injection of 8 ml kg^-1 of diatrizoate. Serum Cr returned to a level comparable with baseline (pre insult) 7 days after the injection of diatrizoate(n=5).