Figure 2. Effects of the high osmolar diatrizoate and low osmolar iopromide on renal function of rats pre-treated with indomethacin and L-nitroarginine methyl ester (L-NAME). (a) Serum creatinine (Cr) before () and 24 h after () injection of either 6 ml kg^-1 of diatrizoate (Group 1) or iopromide (Group 2). Significant increases (^*p<0.01) in serum Cr occurred in both groups, but the rise in Group 1 was significantly higher (p<0.05) than in Group 2 (n=5 per group). (b) Percentage in Cr clearance from baseline (24 h pre injection) to 24 h post injection of 6 ml kg^-1 of diatrizoate (Group 1) or iopromide (Group 2). Significant decreases (^*p<0.01) in Cr clearance occurred in both groups, but the reduction in Group 1 was more severe (p<0.05) than in Group 2 (n=5 per group).